Table 2.

Discrimination of Screening Thresholds for 5-Year Progression to ESKD.

Screening methods and risk thresholds	Sensitivity	Specificity	Positive predictive value	Negative predictive value
KFRE
>3% risk of progression to ESKD	0.967	0.619	0.220	0.994
>10% risk of progression to ESKD	0.861	0.802	0.325	0.981
eGFR
<30 mL/min/1.73 m2	0.623	0.837	0.297	0.952
<45 mL/min/1.73 m2	0.841	0.544	0.170	0.969
Prior nephrology visit	0.788	0.636	0.193	0.964

Note. Overall C statistic for KFRE: 0.900 (95% CI, 0.876-0.923), overall C statistic for eGFR: 0.784 (95% CI, 0.742-0.826), and overall C statistic for prior nephrology visit: 0.712 (95% CI, 0.677-0.747). ESKD = end-stage kidney disease; KFRE = Kidney Failure Risk Equation; CI = confidence interval; eGFR = estimated glomerular filtration rate.