Table 2. A variety of human pathogens bear putative histone-like sequences.
The viral proteins that are homologous to the H3K4- or H3K9/H3K27-sequences in histone H3 are shown. The position of the putative viral histone mimics, with respect to the carboxy- or amino-termini, as well as the cellular localization of the viral proteins is indicated.
| Viral protein with H3K4-like sequence | Accession | Motif | Distance from terminus | Terminus | Localization |
|---|---|---|---|---|---|
|
| |||||
| Non structural protein 1 [Influenza A virus (A/New York/392/2004(H3N2))] | YP_308845.1 | ARSK | 4 | C | Nuclear |
| DNA polymerase catalytic subunit [Human herpesvirus 6A] | NP_042931.1 | ARSK | 72 | N | Nuclear |
| E2 protein [Semliki forest virus] | NP_819006.1 | ARSK | 31 | C | Membrane |
| Attachment glycoprotein G [Human metapneumovirus] | YP_012612.1 | ARSK | 23 | N | Membrane/Cytoplasm |
| Truncated structural polyprotein [Semliki forest virus] | YP_006390078.1 | ARSK | 106 | C | Membrane/Cytoplasm |
| NS5b [Hepatitis C virus genotype 3] | YP_001491557.1 | ARSK | 97 | N | Perinuclear |
| Envelope glycoprotein B [Human herpesvirus 5] | YP_081514.1 | ARSK | 257 | N | Membrane/Perinuclear |
| HCV polyprotein [Hepatitic C virus genotype 4] | YP_001469632.1 | ARSK | 494 | C | Varied |
| Polyprotein [Hepatitis C virus genotype 5] | YP_001469633.1 | ARSK | 494 | C | Varied |
| Polyprotein [Hepatitis C virus genotype 2] | YP_001469630.1 | ARSK | 494 | C | Varied |
| Viral protein with H3K9/H3K27-like sequence | Accession | Motif | Distance from terminus | Terminus | Localization |
|---|---|---|---|---|---|
|
| |||||
| Pol [Human adenovirus 35] | AP_000576.1 | ARKS | 28 | N | Nuclear |
| DNA polymerase [Human adenovirus B] | YP_002213842.1 | ARKS | 28 | N | Nuclear |
| Encapsidation protein IVa2 [Human adenovirus C] | NP_040515.1 | ARKT | 5 | C | Nuclear |
| IVa2 [Human adenovirus 2] | AP_000165.1 | ARKT | 5 | C | Nuclear |
| IVa2 [Human adenovirus 5] | AP_000201.1 | ARKT | 5 | C | Nuclear |
| IVa2 [Human adenovirus 1] | AP_000502.1 | ARKT | 5 | C | Nuclear |
| E2 protein [Human papillomavirus type 88] | YP_001672011.1 | ARKS | 52 | N | Nuclear |
| Single-stranded DNA-binding protein [Human adenovirus D] | YP_001974427.1 | ARKT | 72 | N | Nuclear |
| ORF29 [Human herpesvirus 8] | YP_001129382.1 | ARKT | 126 | N | Nuclear |
| BALF5 [Human herpesvirus 4] | YP_401712.1 | ARKT | 60 | C | Nuclear |