Fig. 1.

Model schematic. BC, breast cancer; OC, ovarian cancer; RRS, risk-reducing surgery. ^†An age of all-cause mortality was estimated for each individual using UK national life tables, and an annual age-adjusted risk of death was estimated for individuals with cancer. ^‡The age at which risk-reducing bilateral salpingo-oophorectomy occurred was assumed to be 40 years in BRCA1 mutation–positive individuals and 45 years in BRCA2 mutation–positive individuals, or on model entry for individuals older than these ages. The age of risk-reducing mastectomy was assumed to be 40 years or on model entry for older individuals.