Figure 6.

Figure 6. Cataloguing and functional clustering of DEG human orthologs through engagement of Ingenuity Pathway Analysis (IPA) tool. (A) Bar-graphs denoting fly-ovary DEGs with statistically significant (P < 0.05) homologies to human counterparts and their cognate reconstructed protein pathways. Ratio is referred to the number of genes from our DEG list [comparison of their transcriptional activities between SE (sham exposed) and EXP (truly exposed) fly groups] divided by the total number of genes involved in each specific pathway that has been notably affected by flies' exposure to mobile-phone radiation. Threshold is determined at P value 0.05 [-log (0.05) = 1.30]. To the same direction, RF-radiation exposure proved able to differentially perturb the transcriptional-expression profiling of several genes (DEG human orthologs) being critically implicated in: (B) “Cell Cycle” - “Cell Signaling,” (C) “Cell Death” - “Cell Survival,” (D) “DNA Replication” - “DNA Recombination” - “DNA Repair” and (E) “Embryonic Development,” as clearly revealed through suitable application of IPA bioinformatics tool. Red color indicates the upregulated gene products, while green color specifies the downregulated ones. Figures were automatically produced via IPA-software protocols.