Table 3.
DEGs with putative binding sites of ROS-dependent transcription factors. Catalog of fly-ovary DEGs being characterized by the in silico presence (P < 10−4) of the, herein, denoted transcription-factor (AP-1, FOXO3, FOXO4, HIF-1α, NRF2, p53 and REL/NFκB) binding sites in their (DEGs) (semi-)proximal -respective- promoter regions [-1 to −500 bp, upstream (5′) from the transcription start site (TSS: +1)]. Each one of the, herein, examined transcription factors has been previously reported to critically control redox homeostasis under certain cellular settings and stress conditions [41–45]. Identification of binding sites was performed with FIMO algorithm from MEME suite (http://meme-suite.org/) [46] with default settings, using the motifs identified from JASPAR database (http://jaspar.genereg.net), a high-quality transcription factor-binding profile database. The number of times (x) a binding site is recognized in an examined-gene (DEG) promoter is described in its respective parenthesis (e.g., 2x or 3x), when required to be given.
| AP-1[41] | FOXO3[42] | FOXO4[42] | HIF-1α[43, 44] | NRF2[43, 44] | p53[42, 44] | REL (NFκB)[43–45] | |
|---|---|---|---|---|---|---|---|
| CG1732 | + (2x) | + | + | + | |||
| CG7726 (RpL11) | + | + | + (2x) | + | |||
| CG8389 | + (2x) | + | + (2x) | ||||
| CG3815 | + | + | + | ||||
| CG5170 (Dp1) | + (2x) | ||||||
| CG18468 (Lhr) | + (2x) | ||||||
| CG10107 | + | ||||||
| CG14513 (Yemα) | + (3x) | ||||||
| CG32019(Bt) | + | + | + | ||||
| CG2092 (Scra) | + | ||||||
| CG17697(Fz) | + | ||||||
| CG7184 (Mkrn1) | + | + | |||||
| CG6536 (Mthl4) | + | ||||||
| CG6401 | + | ||||||
| CG6190 (Ube3a) | + | ||||||
| CG30466 | + | ||||||
| CG17540 (Spf45) | + | ||||||
| CG14411 | + | ||||||
| CG1093(Plx) | + | ||||||
| CG10738 | + | ||||||
| CG5276 | + | + | + | ||||
| CG5871 | + | + | + (2x) | ||||
| CG8320 | + | ||||||
| CG6791 | + (2x) | ||||||
| CG32627 (NnaD) | + | ||||||
| CG11783 (Hr96) | + | ||||||
| CG2641 | + | + | + | ||||
| CG9485 | + | + | |||||
| CG7465 | + | + | |||||
| CG6977 (Cad87A) | + | + | |||||
| CG6958 (Nup133) | + (2x) | + (2x) | |||||
| CG6072 (Sra) | + | + | |||||
| CG5976 | + | + | |||||
| CG3870 (Chrw) | + | + | |||||
| CG32155 | + | + | |||||
| CG2186 | + | + | |||||
| CG17596 (S6kII) | + | + | |||||
| CG17370 | + (3x) | + (3x) | |||||
| CG14516 | + | + | |||||
| CG13350 | + | + | |||||
| CG10961 (Traf6) | + | + | |||||
| CG10959 | + | + | |||||
| CG10653 (Hk) | + | + | |||||
| CG12214 | + | + | + | ||||
| CG8332 (RpS15) | + | + | |||||
| CG7685 | + | + | |||||
| CG3194 | + | + | |||||
| CG1866 (Moca-cyp) | + | + | |||||
| CG17261 | + | + | |||||
| CG10265 | + | + | |||||
| CG5742 | + | ||||||
| CG9007 | + | ||||||
| CG6718 (IPLA2-VIA) | + | ||||||
| CG32315 (Dlt) | + | ||||||
| CG7162 (MED1) | + | ||||||
| CG6148 (Past1) | + |