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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Gastroenterology. 2017 Jan 26;152(6):1449–1461.e7. doi: 10.1053/j.gastro.2017.01.015

Figure 6. Effect of SAMe administration on histology and serology in MAT1A KO mice.

Figure 6

A) Representative images of hematoxylin and eosin (H&E), Sudan III red, Sirius red and F4/80 immunofluorescence staining of liver tissues after eight weeks SAMe (30 mg/kg/day) or vehicle administration are shown. Sizing bars correspond to 100 µm for H&E and Sirius Red, and 50 µm for Sudan III and F4/80. Quantitative analyses are shown in the table. Results that were significantly different (P<.05) to vehicle-given MAT1A-KO mice are indicated. Data shown represent mean of twelve vehicle-given MAT1A-KO, twelve SAMe-treated MAT1A-KO and eleven vehicle-given wild type (WT) animals. B) Effect of SAMe administration on serum parameters. For each group of animals (WT + vehicle, MAT1A-KO + vehicle, and MAT1A-KO + SAMe), results that were significantly different (P<.05) before and after administration are indicated. Twelve SAMe-given MAT1A-KO, twelve vehicle-treated MAT1A-KO and eleven vehicle-given WT mice were analyzed.