A) Representative images of hematoxylin and eosin (H&E), Sudan
III red, Sirius red and F4/80 immunofluorescence staining of liver tissues after
eight weeks SAMe (30 mg/kg/day) or vehicle administration are shown. Sizing bars
correspond to 100 µm for H&E and Sirius Red, and 50 µm
for Sudan III and F4/80. Quantitative analyses are shown in the table. Results
that were significantly different (P<.05) to
vehicle-given MAT1A-KO mice are indicated. Data shown represent mean of twelve
vehicle-given MAT1A-KO, twelve SAMe-treated MAT1A-KO and eleven vehicle-given
wild type (WT) animals. B) Effect of SAMe administration on serum parameters.
For each group of animals (WT + vehicle, MAT1A-KO + vehicle, and MAT1A-KO +
SAMe), results that were significantly different
(P<.05) before and after administration are indicated.
Twelve SAMe-given MAT1A-KO, twelve vehicle-treated MAT1A-KO and eleven
vehicle-given WT mice were analyzed.