Figure 5.

‘Whole‐of‐life’ deletion (knockout) of the relaxin‐3 or the Rxfp3 gene results in circadian hypoactivity in adult mice (adapted from Smith et al., 2012; Hosken et al., 2015). The distance travelled on home‐cage voluntary running wheels by male and female Rln3 (Smith et al., 2012) and Rxfp3 (Hosken et al., 2015) gene knockout mice is markedly less than their wildtype littermates, possibly reflecting a reduced level of sustained attention or motivation. Distance is shown as m·h^–1 during an average 24 h day. Grey shading indicates the dark phase.