Table 2.
Summary of the effects of exogenous in vivo relaxin treatment on passive mechanical wall properties in rats
| Sex | Age (weeks) | Treatment duration | Vessel | Effect of serelaxin | Reference |
|---|---|---|---|---|---|
| F | 12–14 | 5 days | small renal artery | ↑ passive compliance, outward hypertrophic remodelling | Conrad et al. (2004) |
| M | 12 | 5 days | mesenteric artery | ↓ circumferential stiffness & ↑ passive compliance | Jelinic et al. (2014) |
| M | 8–12 | 3, 5 and 10 days | no effect | Jelinic et al., unpublished | |
| F | 20–24 | 3 days | ↑ passive compliance | Li et al. (2005) | |
| F | 10–12; 40–46 | 5 days | no effect | – | |
| F | 10–12 (control) (obese) | Van Drongelen et al. (2011, 2012, 2013) | |||
| F | 10–12 (control) (SHR) | – | |||
| M | 12 | 5 days | FA, FV, MV | no effect | Li et al. (2005); Jelinic et al. (2014) |
| F | 14–16 | 10 days | brain parenchymal artery middle cerebral artery | outward remodelling no effect | Chan and Cipolla (2011) |
| 14 days (WKY and SHR) | brain parenchymal artery middle cerebral artery | ↑ distensibility, outward remodelling no effect | Chan et al. (2013) | ||
| M | 68 (SHR) | 14 days +7 days washout | carotid artery | ↑ distensibility, outward remodelling | Xu et al. (2010) |
FA, femoral artery; FV, femoral vein; MV, mesenteric vein; WKY, Wistar Kyoto rats; M, male; F, female.