Table 2.

Low MW relaxin receptor agonist ML290

Molecular formula (MW)	RXFP1 EC50 (μM; Max. Resp.)	ATP Tox. EC50 (μM; Max. resp.)	Aqueous kinetic solubility in PBS (pH = 7)		Liver microsomal stability (t1/2 in min; at 2 μM)		Plasma stability (% remaining after 2 h)		PK t1/2 in mice (h) at 30 mg·kg−1 i.p.
			μg·mL−1	μM	M	H	M	H	Plasma	Heart
C24H21F3N2O5S (506.5)	0.094 (98%)	9.4 (−85%)	3.5	7	122	161	99	100	8.5	7.5

H, human serum; M, mouse serum. For intraperitoneal injections (i.p.) in pharmacokinetics (PK) studies the following formulation was used: 10% NMP (N‐Methyl‐2‐pyrrolidone) + 10% SolutolHS15 + 10% PEG400 + 70% Saline.