Table 2.
Patients with a positive family history for OCD
| Demographics | General group* | Phenotypic group† | OR (95% CI) or MD (95% CI)‡ | p value§ | |||||
|---|---|---|---|---|---|---|---|---|---|
| Conservative | Unilateral | Bilateral | Multiple | Total | Less potent | Potent | |||
| Number of patients (%) | 20 (19) | 50 (49) | 21 (20) | 12 (12) | 103 (100) | 70 (70) | 33 (32) | ||
| Number of immediate family members, average number per patient (± SD) | 4 (± 1) | 4 (± 1) | 4 (± 1) | 4 (± 1) | 4 (± 1) | 4 (± 1) | 4 (± 1) | −0.1 (−0.5 to 0.4) | 0.777 |
| Positive immediate family history, number (%) | 4/20 (20) | 2/50 (4)¶ | 2/21 (10) | 0/12 (0) | 8/103 (8) | 6/70 (9)¶ | 2/33 (6) | 0.7 (0.1–3.6) | 0.658 |
| Positive extended family history, number (%) | 0/20 (0) | 4/50 (8)¶ | 2/21 (10) | 1/12 (8) | 7/103 (7) | 4/70 (6)¶ | 3/33 (9) | 1.7 (0.3–7.8) | 0.529 |
| Positive immediate and/or extended family history, number (%) | 4/20 (20) | 5/50 (10)¶ | 4/21 (19) | 1/12 (8) | 14/103 (14) | 9/70 (13)¶ | 5/33 (15) | 1.2 (0.4–3.9) | 0.751 |
Data presented as numerator/denominator (frequency) or mean (± SD); * per methods section, groups correspond to nonoperative management, unilateral lesions advanced to surgery, bilateral lesions managed either conservatively or surgically, and patients who underwent multiple procedures for the same lesion; †phenotypically nonpotent = conservative + unilateral groups; phenotypically potent = bilateral + multiple groups; ‡OR and MD calculated for phenotypically severe group as compared with nonsevere group;. § p values correspond to intergroup differences calculated by Fisher’s exact/chi square text or Student’s t-test, as indicated; ¶immediate family includes parents and/or siblings; does not account for those with/without a history of OCD; one patient in the unilateral group had positive immediate family history and a positive extended family history. Therefore, this patient was counted twice in each of these individual groups, but only once in the combined group; OCD = osteochondritis dissecans; OR = odds ratio; CI = confidence interval; MD = mean difference.