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. 2017 Apr 27;8:463. doi: 10.3389/fimmu.2017.00463

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Copyright © 2017 Grassmann, Kremer, Santos, Souza, Pinto and McBride.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Three-dimensional (3D) structures of the βb-outer membrane proteins (OMPs) and mapping of the immunogenic surface-related epitopes (SRE). Structural modeling was performed using I-TASSER, and the structures were visualized and the images generated using PyMOL. Proteins are orientated as following: the upper portion is surface-exposed on the OM and the lower portion is located in the periplasmic space. The orientation was derived from an interpretation of the orientation and structure of the matching PDB structure. Immunogenic major histocompatibility complex-II epitopes (strong binders) for 14 HLAs were predicted using NetMHCII and mapped onto the βb-OMPs structural models. Immunogenic SRE are indicated in purple in each βb-OMP structure.