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. 2016 Oct 7;222(4):1877–1895. doi: 10.1007/s00429-016-1313-y

Fig. 2.

Fig. 2

Confocal fluorescent micrographs showing sagittal cryosections of a–d 12 pcw and e–h 17 pcw human foetal olfactory system immunolabelled with antibodies towards a–d PSA-NCAM (green) and a, b, d S100 (red) or c GAP-43 (red), e–f O4 (green) and S100 (red), g, h vimentin (red) and S100 (green). All scale bars 40 μm. d, f Asterisk shows olfactory nerves merging with the olfactory nerve layer (ONL). a Olfactory epithelium showing PSA-NCAM immunolabelled olfactory receptor neurons and olfactory axons (white arrowheads). b Bundles of PSA-NCAM+ axons (white arrowheads) are ensheathed by S100+ OECs (blue arrowheads). c PSA-NCAM immunoreactivity in the olfactory nerves co-labels closely with GAP-43. d PSA-NCAM immunoreactivity in the ONL. e Strong O4 immunoreactivity overlapped with S100+ OECs in the olfactory nerves but not in the ONL (f), except where ONs asterisk merged with the ONL. g, h Co-labelling of vimentin with S100+ OECs (yellow arrowheads) is observed in g a cross-section of an olfactory nerve and in h the olfactory nerve layer. Olfactory nerve perineurial cells (white arrowheads) express vimentin but not S100. Blue arrowheads show vimentin+ S100− cells within the ONL and glomerular (GL)