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. 2017 Mar 7;19(3):379–384. doi: 10.1007/s11307-017-1069-7

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Anti-CD8 immuno-PET in subcutaneous colorectal immunotherapy model. CT26 murine colon cancer-grafted mice were treated with CD137-agonistic Abs: CD137-treated, CD137-treated/CD8-blocked mice, and control mice (no anti-CD137 therapy) were injected with 89Zr-malDFO-169 cDb and immuno-PET images were acquired at 22 h postinjection. Note the presence of increased CD8+ tumor-infiltrating lymphocytes within the tumor in CD137-treated animal (white arrow, adapted from [56]).