Fig. 6.

Effect of inhibition of p38 or jun kinase on mRNA levels of TF, TNF, or IL-1β in NB4 cells. NB4 cells were exposed for 24 h to 10 μM of the p38 inhibitors SB202190, Birb796, or SB203580 or 10 μM of the jun kinase inhibitor SP600126 and mRNA levels of TF, TNF, or IL-1β quantified by qPCR and expressed relative to that of the corresponding mRNA in control (unexposed cells, incubated in medium alone) NB4 cells. Results are expressed as means ± SEM of six independent experiments. Results obtained with the p38 inhibitors are significant with a p value <0.01