Table 4.
Overview of Hymenoptera venom allergens relevant in Europe (adapted from [32])
| Allergen | Name/function | MW (kDa) | Potential N‑glycosylations |
|---|---|---|---|
| Honeybee allergens (Apis spp.) | |||
| Api m 1 | Phospholipase A2 | 17 | 1 |
| Api m 2a | Hyaluronidase | 45 | 3 |
| Api m 3 | Acid phosphatase | 49 | 2 |
| Api m 4 | Melittin | 3 | – |
| Api m 5b | Allergen C/DPP IV | 100 | 6 |
| Api m 6 | Protease inhibitor | 8 | – |
| Api m 7c | Protease | 39 | 3 |
| Api m 8 | Carboxylesterase | 70 | 4 |
| Api m 9 | Carboxypeptidase | 60 | 4 |
| Api m 10 | CRP/Icarapin | 55 | 2 |
| Api m 11.0101 | MRJP 8 | 65 | 6 |
| Api m 11.0201 | MRJP 9 | 60 | 3 |
| Api m 12d | Vitellogenin | 200 | 1 |
| Bumblebee allergens (Bombus spp.) | |||
| Bom p 1, Bom t 1 | Phospholipase A2 | 16 | 1 |
| Bom p 4, Bom t 4 | Protease | 27 | 0.1 |
| Yellow jacket allergens (Vespula spp.) | |||
| Ves v 1 | Phospholipase A1 | 35 | – |
| Ves v 2.0101a | Hyaluronidase | 45 | 4 |
| Ves v 2.0201a | Hyaluronidase | 45 | 2 |
| Ves v 3b | DPP IV | 100 | 6 |
| Ves v 5 | Antigen 5 | 25 | – |
| Ves v 6 d | Vitellogenin | 200 | 4 |
| Bald-faced hornet allergens (Dolichovespula spp.) | |||
| Dol m 1 | Phospholipase A1 | 34 | 2 |
| Dol m 2 | Hyaluronidase | 42 | 2 |
| Dol m 5 | Antigen 5 | 23 | 0 |
| Hornet allergens (Vespa spp.) | |||
| Vesp c 1 | Phospholipase A1 | 34 | 0 |
| Vesp ma 2 | Hyaluronidase | 35 | 4 |
| Vesp c 5 | Antigen 5 | 23 | 0 |
| European wasp allergens (Polistes spp.) | |||
| Pol d 1 | Phospholipase A1 | 34 | 1 |
| Pol d 4 | Protease | 33 | 6 |
| Pol d 5 | Antigen 5 | 23 | 0 |
MW molecular weight
a,b,dRefer to homologous allergens
cA homologous yellow jacket protease and further honeybee proteases were identified but these have not been described as allergens