Table 2.

Mutations associated with resistance to first- and second-line drugs detected in the M. tuberculosis strains in study.

Strain ID	Mutations
	INH			RIF	AMK/CAP	AMK	CAP	OFX
	inhA prom	inhA ORF	katG	rpoB RRDR	rrs 1400 region	eis prom	tlyA	gyrA QRDR
SUSCEPTIBLE
H37Rv	wt	wt	wt	wt	wt	wt	wt	wt
MtbPT1	wt	wt	wt	wt	wt	wt	wt	wt
MtbPT2	wt	wt	wt	wt	wt	wt	wt	wt
INHR
MtbPT3	wt	wt	S315T	wt	wt	nt	nt	wt
MtbPT4	C-15T	wt	wt	wt	wt	nt	nt	wt
RIFR
MtbPT5	wt	nt	wt	S531L	wt	wt	wt	wt
MtbPT6	wt	nt	wt	S531L	wt	nt	nt	wt
OFXR
MtbBR1	wt	nt	wt	wt	wt	nt	nt	D94N
Poly-DR
MtbBR2	wt	nt	S315T	D516Y	wt	nt	nt	A90V
MDR
MtbBR3	wt	nt	S315T	S531L	wt	wt	nt	wt
MtbBR4	wt	nt	S315T	S531L	wt	wt	nt	wt
MtbBR5	wt	nt	S315T	S531L	wt	wt	nt	wt
MtbPT7	C-15T	S94A	wt	S531L	wt	wt	wt	wt
MtbBR6	wt	nt	D735A	S531L	A1401G	wt	wt	wt
MtbPT8	wt	wt	S315T	S531L	wt/A1401G*	wt	wt	wt
XDR
MtbPT9	C-15T	S94A	wt	S531L	wt	G-10A	ins GT at pos 755/756	S91P
MtbPT10	C-15T	I194T	wt	S531L	A1401G	wt	wt	D94A
MtbPT11	C-15T	I194T	wt	S531L	A1401G	nt	nt	D94A

^*Heteroresistance. AMK, amikacin; CAP, capreomycin; ID, identification; INH, isoniazid; MDR, multidrug resistant; nt, not tested; OFX, ofloxacin; ORF, open reading frame; Poly-DR, poly-drug resistant; Prom, promoter; QRDR, quinolone resistance determining region; RIF, rifampicin; RRDR, rifampicin resistance determining region; wt, wild-type sequence; XDR, extensively drug resistant.