Table 3.

Suggested treatment adaptations based on TCP and NTCP.

Cancer type	Suggested treatment adaptations
	High NTCP	High NTCP	Low NTCP	Low NTCP
	Low TCP	High TCP	Low TCP	High TCP
Breast	Consider the risk of recurrence first If possible, discussion of a mastectomy ± reconstructive surgery without adjuvant RT	Consider no adjuvant RT if elderly Limit large RT fields (consider partial breast RT or IORT)	Increase treatment fields (IMC, axilla) Consider hypofractionation	Consider no adjuvant RT or IORT if elderly Consider hypofractionation and accelerated RT ± partial breast RT or IORT
Prostate	Discuss possibility of surgery RT with rectal spacer RT with transponders Discuss indication of pelvic RT Discuss interest of proton therapy	Active surveillance Focal therapy Brachytherapy RT with rectal spacer RT with transponders with reduced margins	Dose escalation (boost brachytherapy if indicated) Pelvic RT if indicated	Active surveillance Hypofractionation SBRT
Lung	Surgery if possible Discuss hyperfractionation if large volumes	Surgery Very limited SBRT in case of non-operable lesions	Dose escalation Increase nodal volume (ENI) if indicated	SBRT
Rectum Esophagus	Consider the risk of recurrence first Reduce the volume of fields if possible discuss interest of proton therapy	Involved field RT Discuss the need of RT	Dose escalation if boost indicated	Involved field RT Contact therapy
Head and neck	Consider the risk of recurrence first Reduce the volume of fields if possible discuss interest of proton therapy	Involved field RT	Dose escalation Discuss the use of radiosensitizers (e.g., nimorazole)	Involved field RT Hypofractionation
Gynecological tumors	Consider the risk of recurrence first Reduce the volume of fields if possible discuss interest of proton therapy	Involved field RT No adjuvant RT in adjuvant setting	Dose escalation	Involved field RT Hypofractionation
CNS	Consider the risk of recurrence first Proton therapy is mandatory	Involved field RT No adjuvant RT	Dose escalation	Involved field RT Hypofractionation SBRT

TCP, tumor control probability; NTCP, normal tissue complication probability; IORT, intraoperative radiotherapy; RT, radiotherapy; IMC, internal mammary chain; SBRT, stereotactic body radiation therapy; ENI, elective nodal irradiation; CNS, central nervous system.