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. 2017 Apr 27;8:266. doi: 10.3389/fphys.2017.00266

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Copyright © 2017 Gu, Wang, Zhao, Wang, Cong and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LPA induced the expression, secretion and activity of MMP-9 in a dose- and time- dependent manner. Macrophages were treated with the pointed concentrations of LPA for 24 h or with 10 μM LPA for the pointed time course. The mRNA levels (A,E), protein levels (B,F), secretion (C,G) and activity (D) of MMP-9 were detected by RT-PCR, Western Blot, ELISA and gelatin zymography, respectively. LPA induced MMP-9 expression in human peripheral blood monocyte-derived macrophages (H). Data were expressed as mean ± SD of three independent experiments. ^*P < 0.05, compared with control.