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Presence of clinical manifestations in both cohorts
| Symptom | 1994 | 2014 | P value |
|---|---|---|---|
| N (%) | N (%) | ||
| Myalgia, Myositis or muscle weakness | 91 | 54 | <.001 |
| Arthralgia and/or arthritis | 81 | 91 | .04 |
| Chronic fatigue, un-refreshing sleep or sleep disturbances | 95 | 98 | .25 |
| Neurological manifestations (especially associated with demyelination) | 32 | 20 | .05 |
| Cognitive impairment, memory loss | 81 | 78 | .60 |
| Pyrexia | 52 | 64 | .09 |
| Dry eyes and/or dry mouth (sicca) | 72 | 73 | .87 |
