Table 7.

Summary of identified clinical manifestations in reviewed cohorts

References	Cohort (N)	Fatigue	Arthralgia	Myalgia	Sicca	Pyrexia	Neurological symptoms	Memory/cognitive impairment	Other symptoms
Maijers [15]	80	X	X	X	NR	NR	NR	X	Dermatological problems, alopecia, night sweats, depression, GI-symptoms
Cohen Tervaert [3]	32	X	X	X	NR	X	NR	NR	Asthenie
Contant [23]	57	NR	X	NR	X	NR	NR	NR	Raynaud, headache, dizziness, palpitations, diarrhoea transpiration
Contant [24]	63	NR	X	NR	X	NR	X	X	Raynaud, headache, palpitations, diarrhoea, transpiration, night sweats, rashes
Shoaib [25]	26	NR	X	X	X	X	X	NR	Headache, skin rash, Raynaud’s, hair loss, allergies, sensitivity to sunlight and lymph-adenopathy
Cuellar [26]	300	X	X	NR	X	X	X	X	Headache, night sweats, diarrhoea, recurrent infections, dyspnoea, angio-oedema and shoulder pain
Gaubitz [27]	90	X	X	X	X	NR	NR	NR	Night sweats, Raynaud, tingling, photosensitivity, headache, dyspnoea, depression, hoarseness
Giltay [28]	235	NR	X	NR	NR	NR	NR	NR	Skin abnormalities, burning eyes
De Jong [29]	42	X	X	X	X	X	NR	NR	Rashes, oral ulcers
Englert [30]	458	NR	NR	X	NR	NR	NR	X	Night sweats, breast pain, reflux, paraesthesiae, lethargy
Vasey [31]	50	X	X	X	NR	NR	NR	NR	Lymphadenopathy
Vermeulen [32]	319	X	X	X	NR	NR	NR	X	Headache, lymphadenopathy, sore throat
Bridges [33]	156	X	X	X	X	X	NR	X	Pulmonary symptoms, alopecia, ulcers, lymphadenopathy
Freundlich [34]	50	X	X	NR	X	NR	NR	NR	Raynaud, alopecia, lymphadenopathy, night sweats, sore throats
Solomon [35]	176	X	X	NR	X	NR	NR	X	Skin abnormalities, gland enlargement, dysphagia, carpel tunnel syndrome, alopecia
Peters [22]	100	X	X	X	NR	NR	NR	X	Gastrointestinal symptoms, breast pain, rashes
Mehmed [36]	240	X	X	NR	NR	X	X	X	Dysphagia, hair loss, depression, skin rash, headache
Wells [37]	52	X	X	X	NR	X	NR	X	Headaches, swollen glands, back pain, rashes

X present symptom, NR not reported