Table 3.
Cox proportional hazard regression for 1-year all-cause mortality in patients with light-chain cardiac amyloidosis
| Hazard ratio (95% confidence interval), adjusted for age, gender and BMI | P value | |
|---|---|---|
| NYHA class III–IV vs. I–II | 6.55 (1.89–22.75) | 0.003 |
| LV-FS (%) | 0.91 (0.86–0.97) | 0.002 |
| LV-EF (%) | 0.95 (0.91–0.99) | 0.009 |
| Septal MAPSE (mm) | 0.73 (0.58–0.91) | 0.006 |
| DT (ms) | 0.98 (0.97–0.99) | 0.002 |
| E/E′ | 1.05 (1.00–1.10) | 0.038 |
| ET (ms) | 0.98 (0.96–0.99) | 0.001 |
| IVCT (ms) | 1.01 (1.01–1.02) | 0.002 |
| Tei index | 47.04 (7.79–284.10) | <0.001 |
| Tei index ≥0.9 vs. <0.9 | 8.48 (3.27–21.99) | <0.001 |
| GLSsys (%) | 1.18 (1.06–1.33) | 0.004 |
| GLSRsys (S− 1) | 8.33 (1.55–44.78) | 0.014 |
| Septal LSsysapi/bas | 1.36 (0.83–2.23) | 0.223 |
| GLSRdias (S− 1) | 0.24 (0.06–1.01) | 0.051 |
| E/GLSRdias | 1.92 (1.19–3.08) | 0.007 |
| Model including Tei index, NYHA class and other conventional echocardiographic variables | ||
| NYHA class III–IV vs. I–II | 6.79 (1.27–36.39) | 0.025 |
| LV-EF (%) | 1.04 (0.96–1.13) | 0.309 |
| Septal MAPSE (mm) | 0.85 (0.68–1.06) | 0.153 |
| E/E′ | 0.99 (0.92–1.06) | 0.788 |
| Tei index ≥0.9 vs. <0.9 | 12.33 (2.92–52.04) | 0.001 |
| Model including Tei index and deformation variables | ||
| GLSsys ≤13% vs. >13% | 3.88 (0.84–17.93) | 0.082 |
| E/GLSRdias ≥2.0 vs. <2.0 | 1.44 (0.48–4.35) | 0.517 |
| Tei index ≥0.9 vs. <0.9 | 7.01 (2.43–20.21) | <0.001 |