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. 2017 Apr 27;8:254. doi: 10.3389/fphys.2017.00254

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Copyright © 2017 Koussoulas, Gwynne, Foong and Bornstein.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Measurements of I_h-induced rectification and ADP amplitude. The magnitude of the I_h-induced rectification, was measured as the difference between the maximum hyperpolarization and the hyperpolarization at the end of each current step (A). The gradient of this voltage current relationship was measured in the same way as the input resistance of the cell (see Methods) and represents the change in input resistance due to the conductance change underlying the I_h current. The amplitude of an after-depolarizing potential (ADP) was measured from the base of the ADP to its peak amplitude (B).