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. 2017 Apr 19;108(4):632–640. doi: 10.1111/cas.13196

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© 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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SOX2 expression is required for endometrial cancer cell growth via CDKN1A. (a) Western blot analyses. (b) Time course of cancer cell proliferation. (c) Senescence‐associated β‐galactosidase activity analysis in HEC59 cells transfected with SOX2 siRNA or control siRNA. (d) Cell cycle analysis of EN cells was performed using a FACS Aria II instrument after staining of the cells with propidium iodide. (e) CDKN1A mRNA expression levels in HEC59 cells transfected with siRNA targeting SOX2, as analyzed by quantitative real‐time PCR. (f) Chromatin immunoprecipitation assays were used to detect the SOX2‐CDKN1A interaction in HEC59 cells.