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. 2017 Apr 20;108(4):641–652. doi: 10.1111/cas.13183

Figure 1.

Figure 1

Chronic hypoxia induces microRNA (miR)‐210 upregulation in multiple myeloma (MM). (a) MicroRNA expression profiling for four myeloma cell lines and four primary samples under 1% O2 over 48 h. chr, chromosome; FC, fold change; ND, not detected; Pt., patient. (b) Quantitative (q)RT‐PCR of miR‐210 for indicated myeloma cell lines under 1% O2 over 48 h. Bars represent mean ± 95% confidence interval of three independent experiments. ***P < 0.001. Student's t‐test was used to test for significance. (c) Northern blot analysis of miR‐210 in myeloma cell lines under chronic hypoxia. (d) qRT‐PCR analysis of patient samples (n = 15) under 1% O2 over 48 h. Samples were sorted by CD38++ cells and examined by qRT‐PCR analysis. **P < 0.01. Paired t‐test was used to test for significance. PC, plasma cell.