Fig. 3.

Schematic illustration of the Morris-Water Maze experimental design. To analyze long-term memory we performed a Morris water maze test. The apparatus measured 120 cm in diameter. To test long-term memory, latency, path efficiency, mean distance to the platform and the corrected integrated path length during the probe trial were analyzed. Track plot of each individual animal from the probe trial on day 5 are shown. APP/Psen1 mice showed a significant decline in long-term memory performance compared to age-matched wild-type littermates. Methysticin treatment rescued this effect significantly. (Statistics probe trial: one-way ANOVAs with Tukey's multiple comparisons post hoc test). Data represent mean+SEM; n=6; * p<0.05, ** p<0.01 as indicated.