Table 1.
Area under the curve (AUC) from receiver operating characteristic curve analysis and univariate and multivariate logistic regression analysis to predict prostate cancer on transrectal biopsy
| Predictor† | AUC (95% CI)‡ | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | P‐value | OR | 95% CI | P‐value§ | ||
| Neopterin, ng/mL | 0.61 (0.50–0.72) | 2.436 | 0.935–6.339 | 0.068 | 2.558 | 0.781–8.377 | 0.121 |
| Tryptophan, μmol/L | 0.58 (0.49–0.68) | 0.216 | 0.037–1.249 | 0.087 | 0.614 | 0.054–6.924 | 0.693 |
| Kynurenine, μmol/L | 0.56 (0.46–0.67) | 0.524 | 0.190–1.444 | 0.212 | 0.474 | 0.119–1.887 | 0.289 |
| KTR, μmol/mmol | 0.51 (0.40–0.61) | 0.850 | 0.268–2.695 | 0.782 | 0.371 | 0.108–1.681 | 0.381 |
| PSA, ng/mL | 0.69 (0.60–0.78) | 3.144 | 1.681–5.880 | <0.001 | 3.292 | 1.706–6.352 | <0.001 |
| fPSA, % | 0.60 (0.51–0.70) | 0.574 | 0.268–1.228 | 0.152 | NA | NA | NA |
†Predictors were log‐transformed. ‡Obtained according to the DeLong method. §Multivariate models adjusted for neopterin, tryptophan, kynurenine, kynurenine‐to‐tryptophan ratio (KTR), and prostate‐specific antigen (PSA). CI, confidence interval; fPSA, free PSA; HR, hazard ratio; NA, not adopted due to missing values.