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. 2017 Apr 19;108(4):620–631. doi: 10.1111/cas.13177

Figure 2.

Figure 2

PTEN is the target of miR‐155‐5p. (a) MiR‐155‐5p and its putative binding sequence in the 3′‐UTR of PTEN. Mutant miR‐155‐5p binding sites were generated in the complementary site for the seed region of miR‐155‐5p (WT, wild type; Mut, mutant type). (b) MiR‐155‐5p effects on luciferase activity in cells that carried the wild type and mutant type 3′‐UTR of PTEN. n = three repeats with similar results, *P < 0.05 by Student's t‐test. (c) The expression of miR‐155‐5p, and PTEN according to the dose of miR‐155‐5p inhibitor in Hep3B cells and mimics in HepG2 cells; n = three repeats with similar results; *P < 0.05, ***P < 0.001 by Student's t‐test. (d) The expression of PTEN and phosphorylation of Akt according to the dose of miR‐155‐5p inhibitor in Hep3B cells and mimics in HepG2 cells, the intensity of each band was quantified; the value under each lane indicates the relative expression level of the regulators; n = three repeats with similar results. p‐Akt, phosphorylated Akt.