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. 2017 Apr 16;108(4):704–712. doi: 10.1111/cas.13178

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© 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Time course of DNA double‐strand break contents in spheroids following irradiation. (a) Representative measured sites for outer (I) and inner (II) regions of spheroids after irradiation. Bar = 200 μm. (b) Immunofluorescence staining for 53BP1 at the indicated times after 10 Gy irradiation. Bar = 10 μm. (c) Quantitative analysis of 53BP1 foci number. Fifty cells were randomly selected from outer and inner regions and foci numbers were counted. Data represent mean ± SE of three independent experiments. **P < 0.01. N.S., not significant.