Table 1.

The major studies that have contributed to the development of mycobacterial proteomics

Year	Title	Number of identified proteins	Reference
1997	Definition of Mycobacterium tuberculosis culture filtrate proteins by two-dimensional polyacrylamide gel electrophoresis, N-terminal amino acid sequencing, and electrospray mass spectrometry	32	M.G. Sonnenberg and J.T. Belisle [26]
1999	Comparative proteome analysis of Mycobacterium tuberculosis and Mycobacterium bovis BCG strains: toward functional genomics of microbial pathogens	107	P.R. Jungblut et al. [27]
2000	Toward the proteome of Mycobacterium tuberculosis	167	I. Rosenkrands et al. [24]
2003	Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain	739	S. Gu et al. [28]
2004	Complementary analysis of the Mycobacterium tuberculosis proteome by two-dimensional electrophoresis and isotope-coded affinity tag technology	361	F. Schmidt et al. [29]
2005	Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling	1044	K.G. Mawuenyega et al. [30]
2010	Using a label-free proteomics method to identify differentially abundant proteins in closely related hypo- and hypervirulent clinical Mycobacterium tuberculosis Beijing isolates	1668	G.A. de Souza et al. [31]
2011	Comparison of membrane proteins of Mycobacterium tuberculosis H37Rv and H37Ra strains	1578	H. Malen et al. [32]
2011	Characterization of the Mycobacterium tuberculosis proteome by liquid chromatography mass spectrometry-based proteomics techniques: a comprehensive resource for tuberculosis research	1051	C. Bell et al. [33]
2011	Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry	3176	D.S. Kelkar et al. [34]
2013	The Mtb Proteome Library: A resource of assays to quantify the complete proteome of Mycobacterium tuberculosis	3894	O.T. Schubert et al. [23]
2014	Disclosure of selective advantages in the “modern” sublineage of the Mycobacterium tuberculosis Beijing genotype family by quantitative proteomics.	2392	J. de Keijzer et al. [35]
2015	Quantitative proteomic analysis of M. tuberculosis cluster Beijing B0/W148 strains	1868	J. Bespyatykh et al. [36, 37]