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. 2017 Apr 21;7(4):44. doi: 10.3390/brainsci7040044

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Segmentally trisomic regions of DS mouse models. Most of HSA21 is syntenic to the distal end of MMU16. The trisomic regions in several mouse models of DS are compared on the right of the MMU16 (orange bars). The numbers in brackets represent the number of protein-coding genes within each MMU16 region according to Ensembl release 87. Lipi: lipase, member I, Mrpl39: mitochondrial ribosomal protein L39, Scaf4: SR-related CTD-associated factor 4, Hunk: hormonally upregulated Neu-associated kinase, Runx1: runt-related transcription factor 1, Cbr1: carbonyl reductase 1, Dscr3: Down syndrome critical region gene 3, B3Galt5: UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5, Mx2: MX dynamin-like GTPase 2, and Zbtb21: zinc finger and BTB domain containing 21.