Table 1.

Inhibitory efficacy of various compounds on cell proliferation under acidic conditions.

Efficacy	Compounds
Higher at acidic pH	lovastatin, cantharidin manumycin A *, ionomycin **
Lower at acidic pH	aphidicolin, vinblastine sulfate, paclitaxel, aclarubicin, trichostatin A, 17-AAG
No change at acidic pH	mitomycin C, bleomycin sulfate, methotrexate, daunorubicin, actinomycin D, camptothecin, etoposide, cytochalasin D, kenpaullone, cycloheximide, radicicol, cucurbitacin 1, hydroxyurea, doxorubicin

Inhibitory effect on HeLa cell proliferation was measured in media with an initial pH of 7.7 and 6.7 that decreased to 7.4 and 6.6, respectively, after 5 days of culture [14]. * mesothelioma cells [14], ** synovial cells [15].