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. 2017 Apr 21;9(4):37. doi: 10.3390/cancers9040037

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Simultaneous inhibition of Timp1 and AKT impairs more efficiently the survival of metastatic melanoma cells. The metastatic 4C11+ cell line silenced for Timp1 were silenced for AKT and analyzed for their capacity to survive (A) and induce caspase-3 cleavage (B); WT: non-treated cells; non-target (NT): control non-target shRNA; shTimp1#2: clone 2 silenced for Timp1; shTimp1#3: clone 3 silenced for Timp1. siNT: non-target siRNA; siAKT: siRNA specific for AKT. β-actin (Actin) was used as loading control. * p < 0.05, ** p < 0.01.