Table 3.
Main pharmacokinetic parameters of decoquinate in oily suspension with nano- and microparticle following single intramuscular injection at 120 mg/kg dose level in mice liver (n = 2-3).
| Main PK parameters following IM injection | Nano-DQ (0.43 µm) liver |
CV% | Micro-DQ (8.31 µm) liver |
CV% |
|---|---|---|---|---|
| C max (ng/g) | 114.63 ± 7.19 | 6.27 | 455.29 ± 46.03 | 10.11 |
| T max (hr) | 3.36 ± 0.13 | 3.86 | 2.85 ± 0.39 | 13.68 |
| AUCinf. (ng·hr/g) | 127,674 ± 2,475 | 1.94 | 156,410 ± 15,076 | 9.64 |
| t1/2distribution (hr) | 3.14 ± 0.27 | 8.59 | 1.98 ± 0.51 | 25.76 |
| t1/2elimination (hr) | 861.16 ± 22.40 | 2.60 | 1,421.00 ± 40.26 | 2.83 |
|
| ||||
| MIC at 1,344 h (ng/ml)∗ | 47.35 ± 5.17 | 10.93 | ||
∗Value was calculated based on full causal prophylaxis effect for 8 weeks. IM: intramuscular; DQ: decoquinate.