Table 2.
Association of selected variables with HPV-associated laryngeal carcinoma
| Variable | HPV16 status | Cases (N = 300) |
Controls (N = 300) |
Adjusted OR (95% CI)a | ||
|---|---|---|---|---|---|---|
| No. | % | No. | % | |||
| All subjects | − | 280 | 93.3 | 292 | 97.3 | 1.00 |
| + | 20 | 6.7 | 8 | 2.7 | 2.84 (1.21–6.68) | |
| Age (y) | ||||||
| ≤55 | − | 114 | 90.5 | 129 | 97.0 | 1.00 |
| + | 12 | 9.5 | 4 | 3.0 | 3.52 (1.07–11.54) | |
| >55 | − | 166 | 95.4 | 163 | 97.6 | 1.00 |
| + | 8 | 4.6 | 4 | 2.4 | 2.15 (0.62–7.40) | |
| Sex | ||||||
| Male | − | 205 | 93.2 | 203 | 98.5 | 1.00 |
| + | 15 | 6.8 | 3 | 1.5 | 4.74 (1.33–16.90) | |
| Female | − | 75 | 93.8 | 89 | 94.7 | 1.00 |
| + | 5 | 6.2 | 5 | 5.3 | 1.46 (0.40–5.46) | |
| Smoking | ||||||
| Never | − | 57 | 81.4 | 69 | 95.8 | 1.00 |
| + | 13 | 18.6 | 3 | 4.2 | 5.57 (1.41–22.10) | |
| Ever | − | 223 | 97.0 | 223 | 97.8 | 1.00 |
| + | 7 | 3 | 5 | 2.2 | 1.17 (0.81–1.70) | |
| Drinking | ||||||
| Never | − | 98 | 89.1 | 110 | 96.5 | 1.00 |
| + | 12 | 10.9 | 4 | 3.5 | 3.72 (1.09–12.72) | |
| Ever | − | 182 | 95.8 | 182 | 97.8 | 1.00 |
| + | 8 | 4.2 | 4 | 2.2 | 2.06 (0.61–7.00) | |
a
HPV-positive versus HPV-negative in each stratum; ORs were adjusted for age, sex, smoking, and drinking in logistic regression models.