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A typical case of double-hit lymphoma (DHL). (A) Hematoxylin and eosin (H&E) section shows sheets of medium-sized lymphoid cells with blastoid chromatin and mitotic figures. The lymphoma cells are positive for B-cell marker cluster differentiation 20 (CD20) (B); germinal center marker (cluster differentiation 10 (CD10) (C); B-cell lymphoma protein 2 (BCL2) (D); and c-MYC (F); and show a high proliferation rate by Ki-67 (>90%) (E).
