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Viewing the Mcm2-7 ATPase domains from under the C-terminal domain. (A) a visual representation of the left-handed spiral configuration adopted by Mcm2-7 in its bare state [12,13]; (B) a visual representation of the Mcm2-7 hexamer in its relatively planar configuration while present as an inactive Mcm2-7 double hexamer [3,13]; (C) the observed right-handed configuration of Mcm2-7 in its active CMG, DNA-bound state [14].
