Table 3.
Meta-analysis of VDR SNPs and T1D and diabetic nephropathy (DN).
| VDR Gene and Meta-Analysis | Susceptibility to T1D SNPs | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reference | Author | Year | Population | Total | Case | Control | Comparison Groups | ||
| 1 | [76] | Ponsonby et al. | 2008 | Asian, European, Latinos | 18,257 | 2549 | 15,708 | rs1544410, rs10735810 | T1D/control |
| 16 studies | |||||||||
| 2 | [77] | Zhang et al. | 2012 | Asian, European, Latinos | 11,591 | 5335 | 6256 | rs1544410 | T1D/control |
| 26 studies | |||||||||
| 3 | [78] | Wang et al. | 2012 | East Asian | 10,352 | 3854 | 6498 | rs1544410 | T1D/control |
| 25 studies | |||||||||
| 4 | [79] | Wang et al. | 2014 | East Asian, West Asian | 3959 | 1973 | 1986 | rs1544410, rs10735810 | T1D/control |
| 13 studies | |||||||||
| 5 | [81] | Tizaoui et al. | 2014 | Asian, European, Latinos | 8753 | 3332 | 5421 | BAT, bAT | T1D/control |
| 26 studies | |||||||||
| 6 | [82] | Liu et al. | 2014 | French, Polish, Croatian, Irish, Czech Iranian, Chinese | 2734 | 1394 | 1340 | rs10735810 | diabetic + DN/control |
| 8 studies | |||||||||
| 7 | [83] | Sahin et al. | 2017 | Asian, European, Latinos | 2070 | 1053 | 1017 | rs1544410, rs731236 | T1D/control |
| 8 studies | |||||||||
The meta-analysis published by Qin et al. [80] (23 studies, Asian, Latino, African and Caucasian) is not included in the Table because only an abstract was available. “B” allele of the rs154410 (=BsmI) SNP was associated with an increased risk for the development of T1D especially in Asians. rs10735810 (=FokI) and rs731236 (=TaqI).