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. 2017 Apr 26;8:98. doi: 10.1186/s13287-017-0548-8

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — RNF43 regulates the Wnt/β-catenin pathway in GCSLCs. a Western blot of RNF43 expression in cancer cell lines. RNF43 OE leads to downregulation of β-catenin, a key protein in Wnt/β-catenin pathway, as well as reduction of TCF4, C-myc, and Lgr5 expression. b Xenograft tumor tissues were analyzed for RNF43, β-catenin, and Sox-2 expression by immunohistochemistry. Scale bar, 10 μm (black) and 25 μm (red) (Color figure online). OE overexpression