Table 5.
Odds ratios of S-NS (with 95% confidence intervals) according to gender, syphilitic serological characteristics and serum creatine kinase levels
| Serum RPR titer <1:4 | Serum RPR titer ≥1:4 | |||||||
|---|---|---|---|---|---|---|---|---|
| Serum TPPA titer <1:2560 | Serum TPPA titer ≥1:2560 | Serum TPPA titer <1:2560 | Serum TPPA titer ≥1:2560 | |||||
| Normal CK | Elevated CK | Normal CK | Elevated CK | Normal CK | Elevated CK | Normal CK | Elevated CK | |
| S-NS | ||||||||
| Female | 1.0 (Ref.) | n.a.a | 6.500 * (1.273-33.201) | n.a.b | 2.437 (0.502-11.845) | n.a.c | 20.583 * (5.853-72.380) | n.a.d |
| Male | 1.264 (0.450-3.550) | 3.900 (0.734-20.709) | 9.286 * (2.549-33.832) | 9.750 * (1.340-70.966) | 4.643 * (1.107-19.475) | 6.500 (0.357-118.370) | 53.300 * (18.073-157.194) | n.a.d |
| Confirmed neurosyphilis | ||||||||
| Female | 1.0 (Ref.) | n.a.a | 9.750 (0.507-187.526) | n.a.b | 4.875 (0.275-86.351) | n.a.c | 104.000 * (11.575-934.402) | n.a.d |
| Male | 1.083 (0.095-12.329) | n.a.e | n.a.e | 39.000 * (2.397-634.654) | 11.143 (0.886-140.119) | n.a.e | 265.200 * (32.704-2150.534) | n.a.d |
| Probable neurosyphilis | ||||||||
| Female | 1.0 (Ref.) | n.a.a | 5.850 * (1.004-34.100) | n.a.b | 1.950 (0.320-11.888) | n.a.c | 3.900 (0.734-20.709) | n.a.d |
| Male | 1.300 (0.427-3.959) | 4.680 (0.849-25.811) | 11.143 * (2.913-42.620) | 3.900 (0.297-51.196) | 3.343 (0.647-17.267) | 7.800 (0.419-145.200) | 10.920 * (3.176-37.549) | n.a.d |
S-NS symptomatic neurosyphilis, N-NS syphilis/non-neurosyphilis, RPR rapid plasma reagin, TPPA T. pallidum particle agglutination, CK creatine kinase, OR odds ratio, Ref. reference, n.a. not applicable
* P<0.05
aNo female patient with serum RPR titer <1:4, TPPA titer <1:2560 and elevated CK was in the S-NS group; the OR of S-NS was not applicable
bNo female patient with serum RPR titer <1:4, TPPA titer ≥1:2560 and elevated CK was in the N-NS group; the OR of S-NS was not applicable
cNo female patient with serum RPR titer ≥1:4, TPPA titer <1:2560 and elevated CK was in both groups; the OR of S-NS was not applicable
dIn both male and female patients, there was no one with serum RPR titer ≥1:4, TPPA titer ≥1:2560 and elevated CK in the N-NS group; the OR of S-NS was not applicable
eNo male patient with serum RPR titer <1:4, TPPA titer <1:2560 and elevated CK, or serum RPR titer <1:4, TPPA titer ≥1:2560 and normal CK, or serum RPR titer ≥1:4, TPPA titer <1:2560 and elevated CK was in the confirmed neurosyphilis subgroup; the OR of confirmed neurosyphilis was not applicable