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. 2017 Apr 26;8:101. doi: 10.1186/s13287-017-0550-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — A high concentration of IFN-γ decreases bone-related protein mRNA expression in C-MSC. a-d C-MSCs were treated with or without various doses of IFN-γ (10, 50, 100 ng/mL) for 24 h. The plot shows the ratio of OPN, OC, ALPase, and BMP-2 mRNAs to GAPDH mRNA. Values represent means ± S.D. of four cultures. Values represent means ± S.D. of four cultures. ^* p < 0.05, ^** p < 0.01: values differ significantly (t test). Similar results were obtained from three experiments. ALPase alkaline phosphatase, BMP bone morphogenic protein, GAPDH glyceraldehyde-3-phosphate dehydrogenase, IFN interferon, OC osteocalcin, OPN osteopontin