Table 2.
Mean annual exacerbation rate per patient year in the 12 months post-index date by covariate
| US database (N = 222,817) Rate (95% CI) |
UK database (N = 211,807) Rate (95% CI) |
||
|---|---|---|---|
| Overall | 0.161 (0.159, 0.163) | 0.110 (0.109, 0.111) | |
| GINA Step | Step 1 | 0.139 (0.136, 0.142) | 0.066 (0.063, 0.069) |
| Step 2 | 0.143 (0.138, 0.147) | 0.070 (0.067, 0.073) | |
| Step 3 | 0.153 (0.148, 0.158) | 0.086 (0.084, 0.089) | |
| Step 4 | 0.186 (0.181, 0.191) | 0.126 (0.123, 0.130) | |
| Step 5 | 0.455 (0.434, 0.478) | 0.512 (0.490, 0.536) | |
| Not classifiable/none | 0.105 (0.078, 0.142) | 0.113 (0.084, 0.150) | |
| Exacerbations during the 12-month pre-index period | 0 | 0.110 (0.109, 0.112) | 0.070 (0.069, 0.071) |
| 1 | 0.308 (0.301, 0.315) | 0.273 (0.265, 0.282) | |
| 2 | 0.674 (0.638, 0.712) | 0.644 (0.601, 0.690) | |
| 3 | 1.150 (1.036, 1.276) | 1.236 (1.080, 1.414) | |
| ≥4 | 2.195 (1.925, 2.504) | 2.687 (2.269, 3.183) | |
| Severe uncontrolled asthmaa | Yes | 1.016 (0.939, 1.099) | 1.088 (1.002, 1.181) |
| No | 0.153 (0.151, 0.155) | 0.098 (0.096, 0.100) | |
| Severe uncontrolled eosinophilic asthmab | Yes | 1.158 (0.828, 1.619) | 1.389 (1.127, 1.712) |
| No | 0.153 (0.148, 0.159) | 0.132 (0.128, 0.136) | |
aDefined as patients at GINA Step 4 or 5 with ≥2 exacerbations in the previous 12 months; bpatients with severe uncontrolled asthma criteria and blood eosinophil counts ≥300 cells/μl at baseline. CI confidence interval, GINA Global Initiative for Asthma