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. 2017 Apr 26;14:93. doi: 10.1186/s12974-017-0868-8

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — GlyCAM1 in the ONH is sulfated whereas GlyCAM1 in the inner retina is un-sulfated. We tested tissue for binding of MECA-79, an antibody which is dependent on sulfation to bind to GlyCAM1. Co-localization of MECA-79 (green) and GlyCAM1 (red) determined that the GlyCAM1 present in the vasculature local to the optic nerve is sulfated (white arrows, a, b) and that the GlyCAM1 present in the inner retina and within capillaries within the optic nerve is un-sulfated (white arrows, c and inset d). Scale bars = 50 μm (a, c), 20 μm (b, d), n = 4/group