Table 4.
Indirect calorimetry, activity, and food intake analysis of HFD-fed mice
| Male |
Female |
|||
|---|---|---|---|---|
| WT | KO | WT | KO | |
| n | 6 | 8 | 10 | 13 |
| Food intake, g | 10.6 ± 0.2 | 10.3 ± 0.2 | 2.37 ± 0.13 | 2.56 ± 0.10 |
| V̇o2, ml·kg−1·hour−1 | 2,223 ± 46 | 2,176 ± 53 | 2,691 ± 112 | 2,539 ± 59 |
| V̇co2, ml·kg−1·h−1 | 1,681.3 ± 121 | 1,647 ± 38 | 1,997 ± 81 | 1,927 ± 49 |
| RER (V̇o2/V̇co2) | 0.755 ± 0.01 | 0.75 ± 0.01 | 0.742 ± 0.01 | 0.76 ± 0.01 |
| EE, kcal·kg−1·h−1 | 10.6 ± 0.2 | 10.3 ± 0.25 | 12.73 ± 0.53 | 12.06 ± 0.28 |
| Physical activity (beam breaks) | 26,228 ± 1,291 | 24,607 ± 1,557 | 39,657 ± 3,664 | 34,105 ± 2,948 |
Values are means ± SE; n is number of mice. HFD, high-fat diet; WT, wild-type; KO, knockout; V̇o2, oxygen consumption; V̇co2, CO2 production; RER, respiratory exchange ratio; EE, energy expenditure.