Fig. 8.

Effect of EthE (30-300 mg/kg, p.o.), morphine (1-10 mg/kg, i.p.) and diclofenac (10-100 mg/kg, i.p.) on time course curves (a, c and e) of carrageenan-induced mechanical hypernociception in rats and total nociceptive score (b, d and f) (calculated as AUC). Each data represents the mean of 5 animals and the error bars indicate S.E.M. The symbols * and † indicate the significance levels compared to respective controls: ***P < 0.001, **P < 0.01 *P < 0.05 (two – way ANOVA followed by Bonferroni’s post hoc). †††P < 0.001, ††P < 0.01 and †P < 0.05 (one-way ANOVA followed by Newman-Keuls’ post hoc)