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. 2017 Apr 26;17:6. doi: 10.1186/s12861-017-0148-y

Table 2.

Tissue-specific Cre recombinase drivers and their relationship to cardiovascular lineages

Cre driver Time of deletion [E] Tissue Cardiac and vascular derivatives at E14.5 - E15.5
Sox2Cre [19] 6.5 Epiblast All embryonic tissues.
Wnt1Cre [15, 51] 8.5 Neural crest Aorticopulmonary septum, conotruncal cushions, 3rd, 4th and 6th pharyngeal arch arteries.
Hoxa3Cre [22, 44, 52] E8.0 - E9.0 Pharyngeal arch lineages (endo, meso and ectoderm), caudal to the second arch (PA 3–6). Pharyngeal arch arteries (smooth muscle cells), myocardium of a distal outflow tract and the base of the pulmonary trunk, outflow tract cushions.
Mesp1Cre [31–33] 6.5–7.0 Extraembryonic, lateral, cranio-cardiac, and pharyngeal mesoderm. Myo-, endo- and epicardium, pharyngeal arch arteries.
Nkx2.5Cre [21, 36, 38] 7.5–7.75 Myocardial precursors of primary and secondary heart fields, pharyngeal endoderm and ectoderm of the first pharyngeal arch, proepicardium. Myocardium; endothelium of coronary arteries, cardiac chambers, and valves; smooth muscle cells of the aorta and coronary arteries.