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. 2017 Apr 20;130(8):906–913. doi: 10.4103/0366-6999.204101

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Copyright: © 2017 Chinese Medical Journal

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Expression of IL-1β and TLR4 in renal tissues of all groups of rats (n=9 in each group). (a) The levels of IL-1β and TLR4 in the kidney tissues determined by reverse transcription polymerase chain reaction. (b) The levels of IL-1β and TLR4 in the kidney tissues determined by Western blots. Representative results are shown at the top. Values are expressed as the mean ± standard deviation. *Compared to Control_TAK242, P < 0.05; ^†Compared to IgAN_TAK242, P < 0.05; ^‡Compared to Control_Pio, P < 0.05; ^§Compared to IgAN_Pio, P < 0.05. IgAN: Immunoglobulin A nephropathy; Pio: Pioglitazone; TAK242: Toll-like receptor 4 inhibitor; IL-1β: Interleukin-1 beta; mRNA: Message ribonucleic acid; TLR4: Toll-like receptor 4; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase.