Table 1.
Details of the individual studies included in the meta-analysis
| Author (year) | Country (ethnicity) | Case/control, n | Association of allele | HWE (χ2/P) | Score (NOS) | Genotyping method | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Numbers | Ile/Ile | Ile/Val | Val/Val | Val allele (%) | OR (95% CI) | P | |||||
| Yarosh et al. (2015)[30] | Russia (Caucasian) | 203/227 | 90/117 | 96/85 | 17/25 | 130/135 | 1.13 (0.83–1.49) | 0.467 | 2.451/0.117 | 8 | PCR-RFLP |
| Lakpour et al. (2013)[33] | Iran (Asian) | 95/26 | 95/26 | 0/0 | 0/0 | 0/0 | NR | NR | NA | 6 | PCR-RFLP |
| Safarinejad et al. (2010)[31] | Iran (Asian) | 166/166 | 102/86 | 59/76 | 5/4 | 69/84 | 0.78 (0.54–1.11) | 0.167 | 7.405/0.006 | 9 | PCR-RFLP |
| Zhou (2016)[27] | China (Asian) | 386/441 | 233/280 | 141/145 | 12/16 | 165/177 | 1.08 (0.85–1.37) | 0.513 | 0.273/0.601 | 8 | MassArray |
| Xiong et al. (2015)[21] | China (Asian) | 479/234 | 249/146 | 221/83 | 9/5 | 239/93 | 1.34 (1.02–1.76) | 0.034 | 3.031/0.082 | 8 | PCR-RFLP |
| Feng et al. (2015)[28] | China (Asian) | 216/198 | 137/141 | 47/43 | 32/14 | 111/71 | 1.58 (1.13–2.21) | 0.007 | 13.598/<0.001 | 7 | Sequencing |
| Tang et al. (2014)[32] | China (Asian) | 246/117 | 167/85 | 79/32* | NR | NR | NR | NA | 6 | PCR-RFLP | |
| Lu (2013)[26] | China (Asian) | 1255/717 | 728/393 | 78/56 | 449/268 | 976/592 | 0.91 (0.79–1.03) | 0.139 | 504.588/<0.001 | 8 | TaqMan |
| Li et al. (2013)[29] | China (Asian) | 236/142 | 156/90 | 73/45 | 7/7 | 87/59 | 0.86 (0.60–1.25) | 0.430 | 0.197/0.657 | 7 | PCR-RFLP |
| Total | 3282/3268 | 1957/1364 | 715/533 | 531/339 | 1777/1211 | 1.06 (0.97–1.15) | 0.216 | ||||
*The numbers of genotype distribution of Ile/Val + Val/Val in cases and controls. OR: Odds ratio; CI: Confidence interval; HWE: Hardy-Weinberg equilibrium; NOS: Newcastle-Ottawa Scale; PCR-RFLP: Polymerase chain reaction-restriction fragment length polymorphism; NR: Not report; NA: Not available.