Table 2.
Association between GSTP1 Ile105Val polymorphism and male infertility risk
| Comparison | Population | Number of studies | Test of association | Heterogeneity | |||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | Model | P | I2 (%) | |||
| Val versus Ile (allele) | Overall | 7 | 1.06 (0.90–1.26) | 0.482 | R | 0.008 | 65.3 |
| Overall in HWE | 4 | 1.12 (0.97–1.29) | 0.116 | F | 0.294 | 19.2 | |
| Asian | 6 | 1.06 (0.87–1.29) | 0.588 | R | 0.005 | 70.3 | |
| Asian in HWE | 3 | 1.21 (0.96–1.32) | 0.162 | F | 0.156 | 46.1 | |
| China | 5 | 1.11 (0.90–1.38) | 0.343 | R | 0.005 | 72.8 | |
| China in HWE | 3 | 1.21 (0.96–1.32) | 0.162 | F | 0.156 | 46.1 | |
| Val/Val versus Ile/Val + Ile/Ile (recessive) | Overall | 7 | 0.97 (0.82–1.14) | 0.683 | F | 0.209 | 28.8 |
| Overall in HWE | 4 | 0.76 (0.51–1.16) | 0.203 | F | 0.945 | 0 | |
| Asian | 6 | 0.99 (0.83–1.17) | 0.860 | F | 0.171 | 35.4 | |
| Asian in HWE | 3 | 0.78 (0.46–1.34) | 0.373 | F | 0.836 | 0 | |
| China | 5 | 0.98 (0.83–1.17) | 0.824 | F | 0.107 | 47.4 | |
| China in HWE | 3 | 0.78 (0.46–1.34) | 0.373 | F | 0.836 | 0 | |
| Val/Val + Ile/Val versus Ile/Ile (dominant) | Overall | 8 | 1.10 (0.91–1.34) | 0.334 | R | 0.012 | 61.1 |
| Overall in HWE | 4 | 1.23 (1.04–1.46) | 0.015 | F | 0.219 | 32.2 | |
| Asian | 7 | 1.07 (0.87–1.33) | 0.517 | R | 0.012 | 63.4 | |
| Asian in HWE | 3 | 1.19 (0.89–1.58) | 0.235 | R | 0.122 | 52.5 | |
| China | 6 | 1.14 (0.92–1.41) | 0.229 | R | 0.029 | 59.8 | |
| China in HWE | 3 | 1.19 (0.89–1.58) | 0.235 | R | 0.122 | 52.5 | |
| Val/Val versus Ile/Ile (additive) | Overall | 7 | 0.96 (0.81–1.14) | 0.644 | F | 0.223 | 26.9 |
| Overall in HWE | 4 | 0.86 (0.56–1.31) | 0.472 | F | 0.879 | 0 | |
| Asian | 6 | 0.97 (0.81–1.15) | 0.701 | F | 0.148 | 38.7 | |
| Asian in HWE | 3 | 0.84 (0.49–1.44) | 0.525 | F | 0.719 | 0 | |
| China | 5 | 1.06 (0.70–1.63) | 0.773 | R | 0.087 | 50.8 | |
| China in HWE | 3 | 0.84 (0.49–1.44) | 0.525 | F | 0.719 | 0 | |
| Ile/Val versus Ile/Ile (heterozygote) | Overall | 7 | 1.06 (0.84–1.35) | 0.619 | R | 0.011 | 63.7 |
| Overall in HWE | 4 | 1.29 (1.08–1.53) | 0.005 | F | 0.251 | 26.8 | |
| Asian | 6 | 1.01 (0.78–1.31) | 0.951 | R | 0.015 | 64.6 | |
| Asian in HWE | 3 | 1.25 (1.03–1.52) | 0.026 | F | 0.167 | 44.1 | |
| China | 5 | 1.09 (0.85–1.41) | 0.499 | R | 0.054 | 57.0 | |
| China in HWE | 3 | 1.25 (1.03–1.52) | 0.026 | F | 0.167 | 44.1 | |
GSTP1: Glutathione S-transferase P1; OR: Odds ratio; CI: Confidence interval; HWE: Hardy-Weinberg equilibrium; R: Random effects model; F: Fixed effects model.