. 2017 Feb 7;215(6):992–999. doi: 10.1093/infdis/jix041

Table 2.

Plasma Concentration of the Endothelial Glycocalyx Layer and Tight and Adherens Junction Markers Measured in the Febrile and Critical Phases

Phase of dengue	Biomarker	DF group (n = 30)	DHF group (n = 50)	Severe plasma leakage group (n = 23)
Febrile phase
	Syndecan-1, ng/mL	30.26 (13.65–159.45)	122.81 (32.46–313.62)^a	256.42 (100.73–414.09)^{a, b}
	Heparan sulfate, pg/mL	148.34 (85.14–399.51)	147 (104.53–523.72)	200.93 (112.88–300.71)
	Chondroitin sulfate, ng/mL	24.56 (20.21–34.58)	34.77 (24.93–44.05)^a	34.62 (24.42–42.62)^a
	Hyaluronan, ng/mL	207.43 (56.35–553.1)	842.91 (105.48–3025.74)^a	1216 (320.2–4229)^a
	Claudin-5, pg/mL	17.42 (11.71–34.56)	28.77 (11.87–52.98)	50.1 (22.7–78.7)^{a, b}
	VE-cadherin, ng/mL	23.01 (19.29–38.69)	22.81 (19.48–30.01)	22.36 (18.85–29.14)
Critical phase
	Syndecan-1, ng/mL	35.91 (15.15–160.21)	264.67 (110.58–471.81)^a	468.87 (278.7–538.06)^{a, b}
	Heparan sulfate, pg/mL	146.65 (89.15–402.73)	131.42 (86.67–309.58)	148.05 (111.45–217.62)
	Chondroitin sulfate, ng/mL	21.07 (19.07–24.33)	25.91 (22.89–29.04)^a	28.62 (25.78–31.15)^a
	Hyaluronan, ng/mL	218.71 (67.07–1792.90)	2720.50 (911.62–4790.03)^a	3230.31 (2361.29–6617.7)^a
	Claudin-5, pg/mL	23.77 (11.66–35.31)	20.01 (10.77–48.13)	81.12 (39.12–118.47)^{a, b}
	VE-cadherin, ng/mL	23.51 (18.09–40.05)	25.06 (20.58–33.42)	31.49 (22.34–41.1)

Data presented as median (interquartile range) for each group. The Mann–Whitney test was used to assess differences between two groups.

Abbreviations: DF, dengue fever; DHF, dengue hemorrhagic fever.

^aSignificant difference from the DF group (P < .05).

^bSignificant difference from the DHF group (P < .05).