Fig. 5.

Acarbose prevented sucrose, maltose, and Polycose from eliciting CPIR (experiment 4). We defined CPIR as a significant increase in plasma insulin concentration (i.e., Δ plasma insulin concentration) within 5 min of initiating licking for the taste stimulus, based on a one-sample t-test (P < 0.05). All B6 mice took a weight-specific number of licks (4.3 licks/g mouse) for isoacceptable concentrations of each carbohydrate solution. For each stimulus, we represent the scores from each mouse as a circle, and the mean score as a horizontal line. We use open circles for taste stimuli that elicited a significant CPIR, and closed circles for solutions that did not. *Mean Δ plasma insulin concentration elicited by the carbohydrate + 5 mM acarbose solution was significantly less than that elicited by the corresponding carbohydrate alone (P < 0.004, unpaired t-test). Abbreviations for each experimental solution are as following: sucrose (Sucr), sucrose + acarbose (Sucr+Ac), maltose (Malt), maltose + acarbose (Malt+Ac), Polycose (Poly), and Polycose + acarbose (Poly+Ac).